Neil Patrick HarrisJohan

Katy PerrySmurfette (voice)

Alan CummingGutsy Smurf (voice)

Hank AzariaGargamel

Paul Reubens…Jokey Smurf (voice)

B.J. Novak…Baker Smurf (voice)

George LopezGrouchy Smurf (voice)

Jonathan WintersPapa Smurf (voice)

Fred ArmisenBrainy Smurf (voice)

Kenan Thompson…Greedy Smurf (voice)

John Oliver…Vanity Smurf (voice)

Jeff Foxworthy…Handy Smurf (voice)

Adam Wylie…Panicky smurf

Tim Gunn

Gary BasarabaHefty Smurf (voice)

Wolfgang Puck…Chef Smurf (voice)